Ralph Hasenhuttl's Southampton welcome Carlo Ancelotti's Everton to St Mary's Stadium. The Toffees come into this riding high after an unbeaten start to the season.
Nuno Espirito Santo's Wolverhampton Wanderers welcome Steve Bruce's Newcastle United to Molineux for the second part of a Super Sunday double-header.
Sean Dyche's Burnley take on Jose Mourinho's Tottenham Hotspur at Turf Moor in Monday Night Football from the Premier League.
Manchester City travel to Stade Vélodrome to take on Marseille in Group C of the UEFA Champions League. This is the first time the two sides have met in European competition.
Liverpool welcome Midtjylland to Anfield in Group D of the UEFA Champions League. Liverpool have lost just one of their last 26 home games in all European competitions.
Chelsea travel to Krasnodar Stadium to face Krasnodar in Group E of the UEFA Champions League. This will be Krasnodar's first ever home Champions League tie.
Juventus host Barcelona in Group G at Juventus Stadium. This will be the first Champions League meeting between Lionel Messi and Cristiano Ronaldo since 2011.
Manchester United host RB Leipzig at Old Trafford in Group H of the UEFA Champions League. United are unbeaten in their last 10 home games against German sides.