Leicester City take on Fulham at the King Power Stadium in the Monday Night Football from the Premier League.
David Moyes's West Ham United take on Dean Smith's Aston Villa at the London Stadium in Monday Night Football action from the Premier League.
Jurgen Klopp's Liverpool side welcome Ajax to Anfield in the UEFA Champions League. Liverpool are on a 14-game unbeaten run against Dutch opposition.
Manchester City travel to face Porto in the UEFA Champions League at the Estadio do Dragao. City have won each of their last three meetings with Porto.
Manchester United welcome PSG to Old Trafford for their UEFA Champions League clash. The away side has won all three of the previous European meetings between United and PSG.
Chelsea face Sevilla in the UEFA Champions League at Ramon Sanchez-Pizjuan Stadium. Chelsea have only won one of their last 10 UCL games against Spanish opponents.