Chelsea and Tottenham go head-to-head in the Premier League as they meet at Stamford Bridge.
Brendan Rodgers's Leicester City welcome Premier League champions Manchester City to the King Power Stadium. Pep Guardiola's side ran out 3-1 winners when the sides met earlier this season.
Mikel Arteta's Arsenal welcome another of his former clubs - Everton - to the Emirates Stadium in the Premier League. A tightly fought reverse fixture at Goodison ended 0-0.
Chelsea and Bayern Munich meet in the Champions League Round of 16 first leg at Stamford Bridge.
Manchester City travel to the Santiago Bernabeu to take on Real Madrid in the first leg of their UEFA Champions League Round of 16 match.
Lyon and Juventus meet in the UEFA Champions League at Parc Olympique Lyonnais as they play their Round of 16 first leg tie.